Prempro FAQs

What is Prempro?

Prempro is a hormone replacement therapy medication that contains two kinds of hormones: estrogens and a progestin. Prempro is given to postmenopausal women who have not had hysterectomies to: reduce hot flashes; treat vaginal dryness, itching, and burning; and, help reduce chances of getting osteoporosis (thin weak bones). Progestin reduces the risk of endometrial cancer in women.

What is the most important information I should know about Prempro?

The Women’s Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, non-fatal heart attacks, and blood clots in women involved with long term use of Prempro. If you are or were taking Prempro, you should have yearly physical and breast exams on a monthly basis. Do not take Prempro if you are pregnant or planning to become pregnant.

What are the possible side effects of Prempro?

Menstrual periods beginning again, including changing menstrual bleeding pattern for up to 6 months (spotting, breakthrough bleeding, prolonged or heavier vaginal bleeding, or vaginal bleeding completely stopping by 10 months); vaginal itching or irritation, or thick, white vaginal discharge. Less common side effects include sharp chest or lower leg (calf) pain, breast lumps, severe headache, shortness of breath, coughing up blood, severe stomach pain or swelling, abnormal vaginal bleeding, mild dizziness, nausea and fluid retention.